TRPV4 activation in mouse submandibular gland modulates Ca2+ influx and salivation

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TRPV4 activation in mouse submandibular gland modulates Ca2+ influx and salivation.

Transient receptor potential vanilloid subtype 4 (TRPV4) is a ligand-gated nonselective cation channel that participates in the transduction of mechanical and osmotic stimuli in different tissues. TRPV4 is activated by endogenous arachidonic acid metabolites, 4α-phorbol-12,13 didecanoate, GSK1016790A, moderate heat, and mechanical stress. TRPV4 is expressed in the salivary glands, but its expre...

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TRPV4 activation in mouse submandibular gland modulates Ca influx and salivation

Zhang Y, Catalán MA, Melvin JE. TRPV4 activation in mouse submandibular gland modulates Ca influx and salivation. Am J Physiol Gastrointest Liver Physiol 303: G1365–G1372, 2012. First published October 18, 2012; doi:10.1152/ajpgi.00366.2012.—Transient receptor potential vanilloid subtype 4 (TRPV4) is a ligand-gated nonselective cation channel that participates in the transduction of mechanical ...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology

سال: 2012

ISSN: 0193-1857,1522-1547

DOI: 10.1152/ajpgi.00366.2012